Toxicology Studies
Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms that arise following exposure to toxic substances. It is the characterization of the toxicity profile of a drug, by identifying its impact on the organ structure and/or its functionality.
Toxicology is important, because it:
- Assesses the severity and reversibility of toxicity.
- Helps understanding the relationship between dose ranges and exposure.
- Determines if (and to what degree) the biologic’s toxicity is dose-dependent.
- Checks which species can be tested.
- Comprehends how chemical or physical agents interact with living organisms that may trigger perturbations in cell function and/or structure or that may initiate repair mechanisms at the molecular, cellular, and/or tissue levels.
By understanding the injuries that could occur to kidneys, the heart, muscles, and other vital organs, toxicology studies help to determine the margin of safety of a drug for its expected clinical dose - it’s a reference in guiding the parameters for clinical trials to maximize safety and minimize risk. Not only do toxicology studies frame trial guidance related to duration, administration routes, and dose escalation, they also help to set the parameters for clinical monitoring (i.e., which organs to assess closely).
Toxicologists will investigate the mechanisms by which these substances exert toxicity, as well as how to detect the presence of these substances in various sample types. Additionally, toxicology also involves assessing how to effectively treat animals and/or individuals who have been exposed to certain toxicants.
The substances that are assessed in Toxicology includes environmental agents and chemical compounds found in nature, as well as pharmaceutical compounds that are synthesized for medical use by humans. These substances may produce toxic effects in living organisms, of which can include, but are not limited to, disturbances in growth patterns, discomfort, disease and even death.
Our Laboratory
Medistri's contract Laboratory is located in the heart of Switzerland to continuously serve the countries most innovative universities, research institutes, start-up companies & large enterprises from the Pharmaceutical, MedTech & BioTech industries.
Our Quality Certificates
Explore our list quality certificates and discover why the world's most innovative healthcare companies choose to work with Medistri.
About us
Founded in 2006, Medistri has been focused on building infrastructure for the healthcare industry. Companies of every size, from startups & university projects to Fortune 500 companies use our services to save time, scale and focus on what they do best.
Are you ready to get started?
Contact us and our qualified team will respond.